Symptomatic SARS-CoV-2 infections display specific IgG Fc structures.
Identifieur interne : 000253 ( Main/Exploration ); précédent : 000252; suivant : 000254Symptomatic SARS-CoV-2 infections display specific IgG Fc structures.
Auteurs : Saborni Chakraborty [États-Unis] ; Karlie Edwards [États-Unis] ; Anthony S. Buzzanco [États-Unis] ; Matthew J. Memoli [États-Unis] ; Robert Sherwood [États-Unis] ; Vamsee Mallajosyula [États-Unis] ; Markus M. Xie [États-Unis] ; Joseph Gonzalez [États-Unis] ; Cindy Buffone [États-Unis] ; Nimish Kathale [États-Unis] ; Susan Providenza [États-Unis] ; Prasanna Jagannathan [États-Unis] ; Jason R. Andrews [États-Unis] ; Catherine A. Blish [États-Unis] ; Florian Krammer [États-Unis] ; Haley Dugan [États-Unis] ; Patrick C. Wilson [États-Unis] ; Tho D. Pham [États-Unis] ; Scott D. Boyd [États-Unis] ; Sheng Zhang [États-Unis] ; Jeffery K. Taubenberger [États-Unis] ; Tasha Morales [États-Unis] ; Jeffrey M. Schapiro [États-Unis] ; Julie Parsonnet [États-Unis] ; Taia T. Wang [États-Unis]Source :
- medRxiv : the preprint server for health sciences ; 2020.
Abstract
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a public health crisis that is exacerbated by our poor understanding of correlates of immunity. SARS-CoV-2 infection can cause Coronavirus Disease 2019 (COVID-19), with a spectrum of symptoms ranging from asymptomatic carriage to life threatening pneumonia and cytokine dysregulation [1-3]. Although antibodies have been shown in a variety of in vitro assays to promote coronavirus infections through mechanisms requiring interactions between IgG antibodies and Fc gamma receptors (FcγRs), the relevance of these observations to coronavirus infections in humans is not known [4-7]. In light of ongoing clinical trials examining convalescent serum therapy for COVID-19 patients and expedited SARS-CoV-2 vaccine testing in humans, it is essential to clarify the role of antibodies in the pathogenesis of COVID-19. Here we show that adults with PCR-diagnosed COVID-19 produce IgG antibodies with a specific Fc domain repertoire that is characterized by reduced fucosylation, a modification that enhances interactions with the activating FcγR, FcγRIIIa. Fc fucosylation was reduced when compared with SARS-CoV-2-seropositive children and relative to adults with symptomatic influenza virus infections. These results demonstrate an antibody correlate of symptomatic SARS-CoV-2 infections in adults and have implications for novel therapeutic strategies targeting FcγRIIIa pathways.
DOI: 10.1101/2020.05.15.20103341
PubMed: 32511463
PubMed Central: PMC7252581
Affiliations:
- États-Unis
- Californie, Illinois, Maryland, État de New York
- Chicago, Ithaca (New York), Stanford (Californie)
- Université Cornell, Université Stanford, Université de Chicago
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Wilson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Pham, Tho D" sort="Pham, Tho D" uniqKey="Pham T" first="Tho D" last="Pham">Tho D. Pham</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Blood Center, Palo Alto, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Blood Center, Palo Alto, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zhang, Sheng" sort="Zhang, Sheng" uniqKey="Zhang S" first="Sheng" last="Zhang">Sheng Zhang</name><affiliation wicri:level="4"><nlm:affiliation>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, 14853, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, 14853</wicri:regionArea><orgName type="university">Université Cornell</orgName><placeName><settlement type="city">Ithaca (New York)</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name><affiliation wicri:level="2"><nlm:affiliation>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Morales, Tasha" sort="Morales, Tasha" uniqKey="Morales T" first="Tasha" last="Morales">Tasha Morales</name><affiliation wicri:level="2"><nlm:affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley</wicri:cityArea></affiliation></author><author><name sortKey="Schapiro, Jeffrey M" sort="Schapiro, Jeffrey M" uniqKey="Schapiro J" first="Jeffrey M" last="Schapiro">Jeffrey M. Schapiro</name><affiliation wicri:level="2"><nlm:affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley</wicri:cityArea></affiliation></author><author><name sortKey="Parsonnet, Julie" sort="Parsonnet, Julie" uniqKey="Parsonnet J" first="Julie" last="Parsonnet">Julie Parsonnet</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Population Health, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32511463</idno><idno type="pmid">32511463</idno><idno type="doi">10.1101/2020.05.15.20103341</idno><idno type="pmc">PMC7252581</idno><idno type="wicri:Area/Main/Corpus">000631</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000631</idno><idno type="wicri:Area/Main/Curation">000631</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000631</idno><idno type="wicri:Area/Main/Exploration">000631</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Symptomatic SARS-CoV-2 infections display specific IgG Fc structures.</title><author><name sortKey="Chakraborty, Saborni" sort="Chakraborty, Saborni" uniqKey="Chakraborty S" first="Saborni" last="Chakraborty">Saborni Chakraborty</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Edwards, Karlie" sort="Edwards, Karlie" uniqKey="Edwards K" first="Karlie" last="Edwards">Karlie Edwards</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Buzzanco, Anthony S" sort="Buzzanco, Anthony S" uniqKey="Buzzanco A" first="Anthony S" last="Buzzanco">Anthony S. Buzzanco</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Memoli, Matthew J" sort="Memoli, Matthew J" uniqKey="Memoli M" first="Matthew J" last="Memoli">Matthew J. Memoli</name><affiliation wicri:level="2"><nlm:affiliation>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Sherwood, Robert" sort="Sherwood, Robert" uniqKey="Sherwood R" first="Robert" last="Sherwood">Robert Sherwood</name><affiliation wicri:level="4"><nlm:affiliation>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, 14853, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, 14853</wicri:regionArea><orgName type="university">Université Cornell</orgName><placeName><settlement type="city">Ithaca (New York)</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mallajosyula, Vamsee" sort="Mallajosyula, Vamsee" uniqKey="Mallajosyula V" first="Vamsee" last="Mallajosyula">Vamsee Mallajosyula</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Xie, Markus M" sort="Xie, Markus M" uniqKey="Xie M" first="Markus M" last="Xie">Markus M. Xie</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Gonzalez, Joseph" sort="Gonzalez, Joseph" uniqKey="Gonzalez J" first="Joseph" last="Gonzalez">Joseph Gonzalez</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Buffone, Cindy" sort="Buffone, Cindy" uniqKey="Buffone C" first="Cindy" last="Buffone">Cindy Buffone</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Kathale, Nimish" sort="Kathale, Nimish" uniqKey="Kathale N" first="Nimish" last="Kathale">Nimish Kathale</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Providenza, Susan" sort="Providenza, Susan" uniqKey="Providenza S" first="Susan" last="Providenza">Susan Providenza</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Jagannathan, Prasanna" sort="Jagannathan, Prasanna" uniqKey="Jagannathan P" first="Prasanna" last="Jagannathan">Prasanna Jagannathan</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Andrews, Jason R" sort="Andrews, Jason R" uniqKey="Andrews J" first="Jason R" last="Andrews">Jason R. Andrews</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea></affiliation></author><author><name sortKey="Dugan, Haley" sort="Dugan, Haley" uniqKey="Dugan H" first="Haley" last="Dugan">Haley Dugan</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C" last="Wilson">Patrick C. Wilson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Pham, Tho D" sort="Pham, Tho D" uniqKey="Pham T" first="Tho D" last="Pham">Tho D. Pham</name><affiliation wicri:level="2"><nlm:affiliation>Stanford Blood Center, Palo Alto, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Blood Center, Palo Alto, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zhang, Sheng" sort="Zhang, Sheng" uniqKey="Zhang S" first="Sheng" last="Zhang">Sheng Zhang</name><affiliation wicri:level="4"><nlm:affiliation>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, 14853, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, 14853</wicri:regionArea><orgName type="university">Université Cornell</orgName><placeName><settlement type="city">Ithaca (New York)</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name><affiliation wicri:level="2"><nlm:affiliation>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Morales, Tasha" sort="Morales, Tasha" uniqKey="Morales T" first="Tasha" last="Morales">Tasha Morales</name><affiliation wicri:level="2"><nlm:affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley</wicri:cityArea></affiliation></author><author><name sortKey="Schapiro, Jeffrey M" sort="Schapiro, Jeffrey M" uniqKey="Schapiro J" first="Jeffrey M" last="Schapiro">Jeffrey M. Schapiro</name><affiliation wicri:level="2"><nlm:affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley</wicri:cityArea></affiliation></author><author><name sortKey="Parsonnet, Julie" sort="Parsonnet, Julie" uniqKey="Parsonnet J" first="Julie" last="Parsonnet">Julie Parsonnet</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Population Health, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">medRxiv : the preprint server for health sciences</title><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a public health crisis that is exacerbated by our poor understanding of correlates of immunity. SARS-CoV-2 infection can cause Coronavirus Disease 2019 (COVID-19), with a spectrum of symptoms ranging from asymptomatic carriage to life threatening pneumonia and cytokine dysregulation [1-3]. Although antibodies have been shown in a variety of <i>in vitro</i> assays to promote coronavirus infections through mechanisms requiring interactions between IgG antibodies and Fc gamma receptors (FcγRs), the relevance of these observations to coronavirus infections in humans is not known [4-7]. In light of ongoing clinical trials examining convalescent serum therapy for COVID-19 patients and expedited SARS-CoV-2 vaccine testing in humans, it is essential to clarify the role of antibodies in the pathogenesis of COVID-19. Here we show that adults with PCR-diagnosed COVID-19 produce IgG antibodies with a specific Fc domain repertoire that is characterized by reduced fucosylation, a modification that enhances interactions with the activating FcγR, FcγRIIIa. Fc fucosylation was reduced when compared with SARS-CoV-2-seropositive children and relative to adults with symptomatic influenza virus infections. These results demonstrate an antibody correlate of symptomatic SARS-CoV-2 infections in adults and have implications for novel therapeutic strategies targeting FcγRIIIa pathways.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32511463</PMID><DateRevised><Year>2021</Year><Month>01</Month><Day>19</Day></DateRevised><Article PubModel="Electronic"><Journal><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>May</Month><Day>18</Day></PubDate></JournalIssue><Title>medRxiv : the preprint server for health sciences</Title><ISOAbbreviation>medRxiv</ISOAbbreviation></Journal><ArticleTitle>Symptomatic SARS-CoV-2 infections display specific IgG Fc structures.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">2020.05.15.20103341</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1101/2020.05.15.20103341</ELocationID><Abstract><AbstractText>The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a public health crisis that is exacerbated by our poor understanding of correlates of immunity. SARS-CoV-2 infection can cause Coronavirus Disease 2019 (COVID-19), with a spectrum of symptoms ranging from asymptomatic carriage to life threatening pneumonia and cytokine dysregulation [1-3]. Although antibodies have been shown in a variety of <i>in vitro</i> assays to promote coronavirus infections through mechanisms requiring interactions between IgG antibodies and Fc gamma receptors (FcγRs), the relevance of these observations to coronavirus infections in humans is not known [4-7]. In light of ongoing clinical trials examining convalescent serum therapy for COVID-19 patients and expedited SARS-CoV-2 vaccine testing in humans, it is essential to clarify the role of antibodies in the pathogenesis of COVID-19. Here we show that adults with PCR-diagnosed COVID-19 produce IgG antibodies with a specific Fc domain repertoire that is characterized by reduced fucosylation, a modification that enhances interactions with the activating FcγR, FcγRIIIa. Fc fucosylation was reduced when compared with SARS-CoV-2-seropositive children and relative to adults with symptomatic influenza virus infections. These results demonstrate an antibody correlate of symptomatic SARS-CoV-2 infections in adults and have implications for novel therapeutic strategies targeting FcγRIIIa pathways.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chakraborty</LastName><ForeName>Saborni</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edwards</LastName><ForeName>Karlie</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buzzanco</LastName><ForeName>Anthony S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Memoli</LastName><ForeName>Matthew J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sherwood</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, 14853, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mallajosyula</LastName><ForeName>Vamsee</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Markus M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gonzalez</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buffone</LastName><ForeName>Cindy</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kathale</LastName><ForeName>Nimish</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Providenza</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jagannathan</LastName><ForeName>Prasanna</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrews</LastName><ForeName>Jason R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blish</LastName><ForeName>Catherine A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krammer</LastName><ForeName>Florian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dugan</LastName><ForeName>Haley</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>Patrick C</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pham</LastName><ForeName>Tho D</ForeName><Initials>TD</Initials><AffiliationInfo><Affiliation>Stanford Blood Center, Palo Alto, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boyd</LastName><ForeName>Scott D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Sheng</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, 14853, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taubenberger</LastName><ForeName>Jeffery K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morales</LastName><ForeName>Tasha</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schapiro</LastName><ForeName>Jeffrey M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parsonnet</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Taia T</ForeName><Initials>TT</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U01 AI150741</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D000076942">Preprint</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>medRxiv</MedlineTA><NlmUniqueID>101767986</NlmUniqueID></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="UpdateIn"><RefSource>Nat Immunol. 2020 Nov 9;:</RefSource><PMID Version="1">33169014</PMID></CommentsCorrections></CommentsCorrectionsList><CoiStatement>Competing interests: The authors declare no competing interests.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32511463</ArticleId><ArticleId IdType="doi">10.1101/2020.05.15.20103341</ArticleId><ArticleId IdType="pmc">PMC7252581</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Illinois</li><li>Maryland</li><li>État de New York</li></region><settlement><li>Chicago</li><li>Ithaca (New York)</li><li>Stanford (Californie)</li></settlement><orgName><li>Université Cornell</li><li>Université Stanford</li><li>Université de Chicago</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Chakraborty, Saborni" sort="Chakraborty, Saborni" uniqKey="Chakraborty S" first="Saborni" last="Chakraborty">Saborni Chakraborty</name></region><name sortKey="Andrews, Jason R" sort="Andrews, Jason R" uniqKey="Andrews J" first="Jason R" last="Andrews">Jason R. Andrews</name><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><name sortKey="Buffone, Cindy" sort="Buffone, Cindy" uniqKey="Buffone C" first="Cindy" last="Buffone">Cindy Buffone</name><name sortKey="Buzzanco, Anthony S" sort="Buzzanco, Anthony S" uniqKey="Buzzanco A" first="Anthony S" last="Buzzanco">Anthony S. Buzzanco</name><name sortKey="Dugan, Haley" sort="Dugan, Haley" uniqKey="Dugan H" first="Haley" last="Dugan">Haley Dugan</name><name sortKey="Edwards, Karlie" sort="Edwards, Karlie" uniqKey="Edwards K" first="Karlie" last="Edwards">Karlie Edwards</name><name sortKey="Gonzalez, Joseph" sort="Gonzalez, Joseph" uniqKey="Gonzalez J" first="Joseph" last="Gonzalez">Joseph Gonzalez</name><name sortKey="Jagannathan, Prasanna" sort="Jagannathan, Prasanna" uniqKey="Jagannathan P" first="Prasanna" last="Jagannathan">Prasanna Jagannathan</name><name sortKey="Jagannathan, Prasanna" sort="Jagannathan, Prasanna" uniqKey="Jagannathan P" first="Prasanna" last="Jagannathan">Prasanna Jagannathan</name><name sortKey="Kathale, Nimish" sort="Kathale, Nimish" uniqKey="Kathale N" first="Nimish" last="Kathale">Nimish Kathale</name><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name><name sortKey="Mallajosyula, Vamsee" sort="Mallajosyula, Vamsee" uniqKey="Mallajosyula V" first="Vamsee" last="Mallajosyula">Vamsee Mallajosyula</name><name sortKey="Memoli, Matthew J" sort="Memoli, Matthew J" uniqKey="Memoli M" first="Matthew J" last="Memoli">Matthew J. Memoli</name><name sortKey="Morales, Tasha" sort="Morales, Tasha" uniqKey="Morales T" first="Tasha" last="Morales">Tasha Morales</name><name sortKey="Parsonnet, Julie" sort="Parsonnet, Julie" uniqKey="Parsonnet J" first="Julie" last="Parsonnet">Julie Parsonnet</name><name sortKey="Parsonnet, Julie" sort="Parsonnet, Julie" uniqKey="Parsonnet J" first="Julie" last="Parsonnet">Julie Parsonnet</name><name sortKey="Pham, Tho D" sort="Pham, Tho D" uniqKey="Pham T" first="Tho D" last="Pham">Tho D. Pham</name><name sortKey="Providenza, Susan" sort="Providenza, Susan" uniqKey="Providenza S" first="Susan" last="Providenza">Susan Providenza</name><name sortKey="Schapiro, Jeffrey M" sort="Schapiro, Jeffrey M" uniqKey="Schapiro J" first="Jeffrey M" last="Schapiro">Jeffrey M. Schapiro</name><name sortKey="Sherwood, Robert" sort="Sherwood, Robert" uniqKey="Sherwood R" first="Robert" last="Sherwood">Robert Sherwood</name><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C" last="Wilson">Patrick C. Wilson</name><name sortKey="Xie, Markus M" sort="Xie, Markus M" uniqKey="Xie M" first="Markus M" last="Xie">Markus M. Xie</name><name sortKey="Zhang, Sheng" sort="Zhang, Sheng" uniqKey="Zhang S" first="Sheng" last="Zhang">Sheng Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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